Smallpox was a systemic disease, officially eradicated since 1979 (WHO), caused by infection with the Variola major virus, whose only reservoir was infected humans.
The transmission of Clostridioides difficile can be patient-to-patient, via contaminated hands of healthcare workers or by environmental contamination.
Rabies is a disease caused by rabies virus (a Lyssavirus). Every year, a small number of cases of rabies is reported in Europe - travel-related or autochthonous.
Dengue is a mosquito-borne viral disease widely spread in tropical and subtropical regions. It is transmitted by Aedes mosquitoes. Most of the clinical cases present a febrile illness, severe forms include hemorrhagic fevers and shock with fatalities.
Genital chlamydia is the leading sexually transmitted infection in Europe and the cause of considerable acute morbidity and long term reproductive health problems, particularly in young people.