Influenza vaccine safety
Adverse reactions following vaccination
Risks of an adverse event following influenza vaccination are far less common than complications related to influenza itself, and the adverse events are generally localized and mild. Adverse reactions are more common in children not previously exposed to the vaccine or virus than in adults. The benefits of vaccination substantially outweigh the risks.
Table 2: Comparison of risks associated with influenza disease and inactivated seasonal influenza vaccination
|
Risks associated with seasonal influenza infection |
Risks associated with inactivated seasonal influenza vaccination* |
|---|---|
|
Common symptoms
|
Common adverse event (<1/100)
|
|
Possible complications
|
Rare adverse event (<1/1000)
|
|
Rare complications
|
Very rare adverse event (<1/10.000)
|
*Reported risks refer to inactivated influenza vaccines commonly used in organised immunisation programmes in the European Union. For details see Summary of Product Characteristics for each vaccine available on national regulatory agency websites.
**Julia Stowe, Nick Andrews, Lesley Wise, Elizabeth Miller Investigation of the Temporal Association of Guillain-Barré Syndrome With Influenza Vaccine and Influenza-like Illness Using the United Kingdom General Practice Research Database, American Journal of Epidemiology, Volume 169, Issue 3, 1 February 2009, Pages 382–388 /C Vellozzi, D Burwen, A Dobardzic, R Ball, K Walton, P Haber Safety of trivalent inactivated influenza vaccines in adults: background for pandemic influenza vaccine safety monitoring, Vaccine, 27 (2009), pp. 2114-2120
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Reports of cases of narcolepsy and cataplexy in children and adolescents in Finland, Iceland, and SwedenArchived
Peer-Reviewed Publication
Early estimates of seasonal influenza vaccine effectiveness in Europe, 2010/11: I-MOVE, a multicentre case-control study
News
Influenza vaccine: selection of strains to be included in the seasonal vaccine for the Northern Hemisphere 2011-2012 – Early indications of seasonal vaccine effectiveness in EuropeArchived
News
Evidence from autopsies on the pathogenesis and pathological findings of the 2009 pandemic influenza A(H1N1) – implications for clinical care and disease burdenArchived
News
The role of social networks in pandemic influenza transmission in and from schools – an example from the United StatesArchived
News
Influenza vaccination of health care workers in hospitals - a review of studies on attitudes and predictorsArchived
News
Knowledge, attitudes and practices of business travelers regarding influenza and the use of antiviral medicationArchived
News
Influenza season 2010/11 – Norway’s risk assessment and revisited vaccine recommendationsArchived
Peer-Reviewed Publication
Estimates of pandemic influenza vaccine effectiveness in europe, 2009-2010: Results of influenza monitoring vaccine effectiveness in Europe (I-MOVE) multicentre case-control study
Peer-Reviewed Publication
Lessons learnt from pandemic A(H1N1) 2009 influenza vaccination. Highlights of a European workshop in Brussels (22 March 2010)
Peer-Reviewed Publication
Overview Of Pandemic Influenza A(h1n1) 2009 Vaccination In Europe. Preliminary Results Of Survey Conducted By Venice, 2010Archived
Peer-Reviewed Publication
Planning for uncertainty: A European approach to informing responses to the severity of influenza epidemics and pandemics
Peer-Reviewed Publication
Pandemic risk prevention in European countries: role of the ECDC in preparing for pandemics. Development and experience with a national self-assessment procedure, 2005-2008.
Peer-Reviewed Publication
Initial surveillance of 2009 influenza A(H1N1) pandemic in the European Union and European Economic Area, April-September 2009.
Peer-Reviewed Publication
Differences in national influenza vaccination policies across the European Union, Norway And Iceland 2008-2009
Publication
ECDC Forward look risk assessment (Update 28 October 2010): Likely scenarios and uncertainties in the 2010/2011 influenza season in Europe and beyond
Peer-Reviewed Publication
Responding to new severe diseases - the case for routine hospital surveillance and clinical networks in Europe
Peer-Reviewed Publication
Study designs for timely estimation of influenza vaccine effectiveness using European sentinel practitioner networks
Peer-Reviewed Publication
Lessons learned from the 2009 Influenza A(H1N1) pandemic at EU level: Editorial
Peer-Reviewed Publication
Evaluation of targeted influenza vaccination strategies via population modeling
Peer-Reviewed Publication
Moderate pandemic, not many dead - Learning the right lessons in Europe from the 2009 pandemic
News
UK announces policies for seasonal influenza vaccination for autumn 2010-2011; including for pregnant womenArchived
Peer-Reviewed Publication
Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic: Insights from modeling
News
Increased seasonal influenza vaccination coverage in the US during the pandemic 2009-10Archived
Peer-Reviewed Publication
Experiences of giving oseltamivir to school children during the 2009 influenza A(H1N1) pandemic
Peer-Reviewed Publication
Measles still spreads in Europe: Who is responsible for the failure to vaccinate?
Peer-Reviewed Publication
Risk groups and other target groups - Preliminary ECDC guidance for developing influenza vaccination recommendations for the season 2010-11
Peer-Reviewed Publication
Experience and lessons from surveillance and studies of the 2009 pandemic in Europe
Peer-Reviewed Publication
A new decade a new seasonal influenza: The Council of the European Union Recommendation on seasonal influenza vaccination
Peer-Reviewed Publication
The end of the pandemic-what will be the pattern of influenza in the 2010-11 European winter and beyond?
Publication
Protocol for cluster investigations to measure influenza vaccine effectiveness in the EU/EEA
Publication
Protocols for cohort database studies to measure influenza vaccine effectiveness in the EU and EEA Member States
Publication
Protocols for case-control studies to measure influenza vaccine effectiveness in the EU and EEA Member States
Peer-Reviewed Publication
Assessing the impact of the 2009 H1N1 influenza pandemic on reporting of other threats through the Early Warning and Response System.
Peer-Reviewed Publication
I-move Towards Monitoring Seasonal And Pandemic Influenza Vaccine Effectiveness: Lessons Learnt From A Pilot Multi-centric Case-control Study In Europe, 2008-9
Peer-Reviewed Publication
Oseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses.
Peer-Reviewed Publication
Seasonal and pandemic influenza vaccines for the elderly and other risk groups: A review of available data
Peer-Reviewed Publication
Influenza A/H1N1 pandemic: central European experience and perspective of prevention and control of this disease [French]
Publication
Interim technical guidance on public health use of influenza antivirals during influenza pandemics
Publication
Interim technical guidance on use of specific pandemic influenza vaccines during the H1N1 2009 pandemic
Peer-Reviewed Publication
Public Health Preparedness For Two Mass Gathering Events In The Context Of Pandemic Influenza (h1n1) 2009-serbia, July 2009
Publication
ECDC rapid risk assessment: Reassortment seasonal influenza virus and swine influenza virus
Peer-Reviewed Publication
Europe's initial experience with pandemic (H1N1) 2009 - mitigation and delaying policies and practices.
Publication
ECDC rapid risk assessment: First isolation of a secondary oseltamivir-resistant A(H1N1)v strain in Denmark
Peer-Reviewed Publication
How the media reported the first days of the pandemic (H1N1) 2009: results of EU-wide media analysis.
Publication
Guide to public health measures to reduce the impact of influenza pandemics in Europe – ‘The ECDC Menu’
Publication
Preliminary report on case-based analysis of influenza A(H1N1) in EU and EEA/EFTA countries
Publication
Technical guidance on mitigation and delaying (or ‘containment’)strategies as the new influenza A(H1N1) virus comes into Europe
Peer-Reviewed Publication
Preliminary Analysis Of Influenza A(h1n1)v Individual And Aggregated Case Reports From Eu And Efta Countries
Peer-Reviewed Publication
Influenza A(h1n1)v In The Southern Hemisphere - Lessons To Learn For Europe?
Publication
Interim ECDC public health guidance on case and contact management for the new influenza A(H1N1) virus infection
Peer-Reviewed Publication
Initial Epidemiological Findings In The European Union Following The Declaration Of Pandemic Alert Level 5 Due To Influenza A (h1n1)
Publication
ECDC rapid risk assessment: Human cases of swine influenza without apparent exposure to pigs, United States and Mexico
News
The United States Advisory Committee on Immunization Practices votes for near universal recommendation for seasonal influenza vaccinationArchived
Peer-Reviewed Publication
A Human Case Of Swine Influenza Virus Infection In Europe - Implications For Human Health And Research
Peer-Reviewed Publication
Use of oseltamivir in 12 European countries between 2002 and 2007 - lack of association with the appearance of oseltamivir-resistant influenza A(H1N1) viruses.
Peer-Reviewed Publication
Differences in European influenza pandemic preparedness plans, how important are they and what are the underlying reasons? [German]
Peer-Reviewed Publication
Start Of The Influenza Season 2008-9 In Europe - Increasing Influenza Activity Moving From West To East Dominated By A(h3n2)
Publication
Training strategy for intervention epidemiology in the European Union - Third ECDC consultation with the Member States
Peer-Reviewed Publication
First steps in the design of a system to monitor vaccine effectiveness during seasonal and pandemic influenza in EU/EEA Member States
Peer-Reviewed Publication
The scientific basis for offering seasonal influenza immunisation to risk groups in Europe.
Publication
Now-Casting and Short-Term Forecasting during Influenza Pandemics - A focused developmental ECDC workshop
Peer-Reviewed Publication
(Yet) another human A/H5N1 influenza case and cluster - when should Europe be concerned?
Peer-Reviewed Publication
Assessing the impact of different BCG vaccination strategies on severe childhood TB in low-intermediate prevalence settings
Peer-Reviewed Publication
European Centre for Disease Prevention and Control issues guidance for the introduction of human papillomavirus (HPV) vaccines in European Union countries.
Peer-Reviewed Publication
Zoonotic infections in Europe: trends and figures - a summary of the EFSA-ECDC annual report.
Peer-Reviewed Publication
H5N1 in wild and domestic birds in Europe - remaining vigilant in response to an ongoing public health threat.
Peer-Reviewed Publication
Public Health Measures in an Influenza Pandemic - the importance of surveillance.
Publication
Meeting report of the Joint EC/ECDC/WHO Workshop on Pandemic Influenza Preparedness in Luxembourg, 25-27 September 2007
Peer-Reviewed Publication
Human influenza A/H5N1 (pre-pandemic") vaccines: informing policy development in Europe."
Publication
Annual Epidemiological Report on communicable diseases in Europe 2007 - Executive Summary [2005 data]
Data
Suggested ‘Acid Tests’ for helping assess, stregthen local preparedness for moderate or severe pandemics
Publication
Infant and children seasonal immunisation against influenza on a routine basis during inter-pandemic period
Peer-Reviewed Publication
Personal (non-pharmaceutical) protective measures for reducing transmission of influenza - ECDC interim recommendations.
Publication
Risk assessment: Avian Influenza A/H5N1 in Bathing and Potable (Drinking) Water and Risks to Human Health
Publication
Risk assessment: The Public Health Risk from Highly Pathogenic Avian Influenza Viruses Emerging in Europe with Specific Reference to type A/H5N1 Version June 1st 2006
Publication
Risk assessment: The Public Health Risk from Highly Pathogenic Avian Influenza Viruses Emerging in Europe with Specific Reference to type A/H5N1
Publication
Avian influenza A/H5N1: Collected risk assessments, technical guidance to public health authorities and advice to the general public
Publication
Third joint EC/ECDC/WHO Workshop on Pandemic Influenza Preparedness - Uppsala, 15 - 17 May 2006
Publication
Oseltamivir Prophylaxis Following Suspected Exposure of Humans to Highly Pathogenic Avian Influenza
Publication
Health advice for people living in or travelling to countries where the A/H5N1 has been detected
Peer-Reviewed Publication
Occurrence of invasive pneumococcal disease and number of excess cases due to influenza
Publication
Avian influenza: Guidance for National Authorities to Produce Messages for the Public Concerning the Protection of Vulnerable Groups
Peer-Reviewed Publication
No new human infections with A/H5N1 in Turkey but national measures and international support continue.
Peer-Reviewed Publication
Nonpharmaceutical interventions for pandemic influenza, international measures
Publication
ECDC Guidelines: Minimise the Risk of Humans Acquiring Highly Pathogenic Avian Influenza from Exposure to Infected Birds or Animals
Institute
NRL for Measles, Rubella, Mumps, Microorganisms resistance monitoring for antibiotics, Neisseria meningitidis, Poliomyelitis, Influenza
ECDC Threat Reports app - direct access to key updates and reports on disease threats of concern to the EU
Influenza communication guidelines: How to increase influenza vaccination uptake and promote preventive measures to limit its spread
Data
Figure 2. Number of influenza cases admitted to selected intensive care units, by (sub-)type and age group; Finland, France, Ireland, Romania, Slovakia, Spain and Sweden; 2014–2015 and 2015–2016
Institute
National Institute of Research and Development for Microbiology and Immunology "Cantacuzino"
ECDC Threat Reports app - direct access to key updates and reports on disease threats of concern to the EU
Data