Rift Valley fever is an acute viral febrile haemorrhagic disease that affects primarily ruminants in Africa and in the Arabian Peninsula: cattle, buffalo, sheep, goats and camels. Humans may become infected by mosquito bites and through direct or indirect contact with the blood or organs of infected animals.
Yellow fever (YF) cause a wide spectrum of symptoms, from mild to fatal. In severe cases there may be spontaneous haemorrhage. Mortality of these clinical cases can be as high as 80%, on a par with Ebola, Marburg and other haemorrhagic viral infections.
West Nile virus (WNV) infection is a mosquito-borne zoonosis. The virus is transmitted among birds via the bite of infected mosquitoes and incidentally humans and other mammals may become infected.
Dengue is a mosquito-borne viral disease widely spread in tropical and subtropical regions. It is transmitted by Aedes mosquitoes. Most of the clinical cases present a febrile illness, severe forms include hemorrhagic fevers and shock with fatalities.
Sindbis virus is widely and continuously found in insects, such as Culex mosquitoes, in Eurasia, Africa, and Oceania. However, clinical infection in humans has almost exclusively been reported in northern Europe where it is endemic and where large outbreaks occur intermittently.