A number of European countries (including Ireland, France, the Netherlands, Sweden and the United Kingdom) indicate an increase seen during 2022, particularly since September 2022, in the number of cases of invasive Group A Streptococcus (iGAS) disease among children less than ten years of age.
Fanny Chereau, EPIET fellow from cohort 2016, was deployed with GOARN (Global Outbreak Alert and Response Network) to support the response to the plague outbreak in Madagascar, on October 2017.
Since 23 August 2017 there is an ongoing epidemic of plague in Madagascar. As of 20 October 2017 WHO has reported 1 365 cases and 106 deaths leading to 8 % case fatality. Nine hundred and fifteen (67%) cases are pneumonic plague cases. The high proportion of pneumonic plague among cases is of concern, indicating that droplet transmission is a driver of the spread of plague in Madagascar beyond the areas that have been considered as endemic for bubonic plague to date. In the last weeks, the number of new confirmed cases seem to be plateauing, indicating that the outbreak is gradually being controlled.
The study design and analysis controlled for influence of potentially confounding trends, such as improvement of day-care carriage and decreasing prevalence of smoking during the study period.
The study compares the incidence and serotype distribution of invasive pneumococcal disease (IPD) for pneumococcal meningitis and non-meningitis IPD in children from 2007 to 2010 with reference to the pre-vaccination period from 1997 to 2001 in Germany.
This study found a marked reduction in vaccine serotype carriage after PCV7 implementation. The overall pneumococcal, H. influenzae and S. aureus carriage decreased slightly, but not significantly.
This study demonstrates that PCV13 is immunogenic and safe in children previously vaccinated with PCV7. By eliciting high antibacterial immune responses to the additional serotypes, PCV13 provides protection against these serotypes, which are important causes of pneumococcal disease globally.
The evidence presented in the article strongly supports the notion that serotype replacement has occurred in invasive pneumococcal disease in most populations and is caused by the vaccine.