Four years of universal pneumococcal conjugate infant vaccination in Germany: Impact on incidence of invasive pneumococcal disease and serotype distribution in childrenArchived

ECDC comment

​The study compares the incidence and serotype distribution of invasive pneumococcal disease (IPD) for pneumococcal meningitis and non-meningitis IPD in children from 2007 to 2010 with reference to the pre-vaccination period from 1997 to 2001 in Germany.

Van der Lindena M, Susanne Weiß S, Falkenhorst G, Siedler A, Imöhl M, von Kries R. Vaccine 30 (2012) 5880-5.

The study compares the incidence and serotype distribution of invasive pneumococcal disease (IPD) for pneumococcal meningitis and non-meningitis IPD in children from 2007 to 2010 with reference to the pre-vaccination period from 1997 to 2001 in Germany.

Globally, S. pneumoniae is the most common cause of bacterial mortality and the most severe cause of bacterial meningitis in children below 5 years of age. With the extensive use of the new conjugate pneumococcal vaccines (PCV7, PCV10 and PCV13) in the EU, monitoring the impact of vaccination and identifying potential further serotype replacement is essential in order to provide information for policy decision markers.