The evidence presented in the article strongly supports the notion that serotype replacement has occurred in invasive pneumococcal disease in most populations and is caused by the vaccine.
The authors present an appraisal of the pneumococcal epidemiological situation in 11 Central European countries. Data are based on study findings presented at the 12th Central European Vaccine Advisory Group (CEVAG) meeting, held on 21–22 May 2010 in Sofia, Bulgaria, and a literature review of the PubMed database.
European Food Safety Authority (EFSA) has issued a new report from its Task Force on the Shiga toxin-producing E. coli (STEC) outbreak in Germany and France. The Task Force has now concluded that one lot of fenugreek seeds imported from Egypt and used to produce sprouts is the most likely common link between the two outbreaks. EFSA continues to advise consumers not to grow sprouts for their own consumption and not to eat sprouts or sprouted seeds unless they have been cooked thoroughly.
In his speech to the Informal Health Council on 5th July, ECDC Director Marc Sprenger outlined the lessons learnt from the EHEC/STEC outbreak in EU, as well as the need to strengthen EU cooperation against epidemics.
On Friday 24 June, France reported a cluster of eight patients with bloody diarrhoea, after having participated in an event in the commune of Bègles around Bordeaux on 8 June. Of these, seven have developed HUS, a severe complication of E. coli infection. In three of the patients, infection with E. coli O104:H4 has been confirmed.
On June 14, Eurosurveillance published new information on the characteristics of the German outbreak strain of E.coli and how these microbiological findings have been shared in real time by public health microbiology experts to disseminate best laboratory practice for case detection and public health investigations across Europe and beyond.
In the context of the ongoing outbreak of Shiga toxin-producing E. coli (STEC) that affects by now citizens from 13 EU member states, it is crucial not only to align the efforts regarding investigation and control of the outbreak but also to share knowledge among practitioners across Europe on the patho-physiological and clinical characteristics of infection caused by this unusual epidemic strain, and review patient management options.
Today, the German authorities published a press release on the current Shiga toxin-producing E.coli outbreak. In their joint statement they recommended in particular to abstain from eating raw sprouts.
In recent years there have been a series of arguments and findings suggesting that Statins (HMG-CoA reductase inhibitors) which used widely to lower cholesterol levels may also be important in reducing the risk associated with severe infective conditions.
The heptavalent pneumococcal conjugate vaccine (PCV7) targets seven of the more than 92 pneumococcal serotypes. Concerns have been raised that non-vaccine serotypes (NVTs) could increase in prevalence and reduce the benefits of vaccination. Indeed, among asymptomatic carriers, the prevalence of NVTs has increased substantially, and consequently, there has been little or no net change in the bacterial carriage prevalence.