This document provides laboratories with a single protocol for producing recombinant full-length hamster prion protein and using it to perform the Real-Time Quaking-Induced Conversion assay (RT-QuIC), which can distinguish sporadic Creutzfeldt-Jakob disease (sCJD) from variant Creutzfeldt-Jakob disease (vCJD).
The National Creutzfeld-Jakob Disease (CJD) Research & Surveillance Unit of the University of Edinburgh organized two one-day information workshops on Real time quaking-induced conversion analysis of cerebrospinal fluid (CSF RT QuIC) diagnostic technique for the investigation of sporadic CJD