Smallpox was a systemic disease, officially eradicated since 1979 (WHO), caused by infection with the Variola major virus, whose only reservoir was infected humans.
Cholera is an acute diarrhoeal infection caused by the bacterium Vibrio cholera of serogroups O1 or O139. Humans are the only relevant reservoir, even though Vibrios can survive for a long time in coastal waters contaminated by human excreta.
Cryptosporidia are intestinal parasites infecting a variety of animals (e.g. cattle, sheep, rodents, cats and dogs, but also birds, fish and reptiles). Human infections occur due to Cryptosporidium parvum, a species that also affects domestic animals.