Findings in this study confirmed the herd immunity effect of immunizing young children, since invasive meningococcal disease was not only reduced among vaccinees, but in all age groups.
Despite long-standing mumps vaccination programmes with high coverage in Europe, a majority of the countries analysed have in recent years experienced mumps outbreaks
In this study, the authors have combined a household method and a school study design to assess VE against mumps as well as VE against mumps infectiousness by comparing secondary attack rates in households of vaccinated and unvaccinated cases.
4CMenB has the potential to reduce serogroup B meningococcal disease substantially. Despite its potential, the vaccine may have some limitations, and it remains to be seen if booster doses will be required to sustain protection.
The authors analyzed data from hospital admissions and enhanced mumps surveillance to assess mumps complications during the largest mumps outbreak in England and Wales, 2004–2005, and their association with mumps vaccination. When compared with non-outbreak periods, the outbreak was associated with a clear increase in hospitalized patients with orchitis, meningitis and pancreatitis. Routine mumps surveillance and hospital data showed that 6.1% of mumps patients were hospitalized, 4.4% had orchitis, 0.35% meningitis and 0.33% pancreatitis.