Systematic review update on the efficacy, effectiveness and safety of newer and enhanced seasonal influenza vaccines for the prevention of laboratory confirmed influenza in individuals aged 18 years and over
In 2020, ECDC conducted a systematic review of the efficacy, effectiveness and safety of newer and/or enhanced seasonal influenza vaccines for the prevention of laboratory-confirmed influenza in individuals aged 18 years and over, which covered literature up to 7 February 2020. In this report, we present an update of the 2020 primary systematic review, to take into account more recent evidence on the efficacy, effectiveness and safety of newer and/or enhanced seasonal influenza vaccines for the prevention of laboratory-confirmed influenza in individuals aged 18 years and over, with a search period from 1 January 2020 to 24 July 2023.
Executive summary
For this update a total of 1 561 new entries in databases were retrieved. After title/abstract and full-text screening, a total of 17 new studies (seven studies on efficacy/effectiveness, 10 studies on safety) were included in the updated review. These 17 newer studies were added to the 42 studies (10 studies on efficacy/effectiveness, 32 studies on safety) which were identified in the primary review, forming a total evidence body of 59 studies analysed. The current report describes the entire body of evidence from both the primary review and this update review. Risk of bias was assessed to be low-to-moderate in all efficacy/effectiveness studies and low-to-serious in safety studies.
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