Download: Maps for Plasmid-mediated colistin resistance in Enterobacteriaceae


The recently recognised global distribution of a self-transferable plasmid-borne colistin resistance gene (mcr-1) poses a substantial public health risk to the EU/EEA because it further limits treatment options in patients with infections caused by multidrug-resistant gram-negative bacteria. It can spread colistin resistance more easily between bacteria and humans than chromosomal mutation.
MDR gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae strains that acquire the mcr-1 gene, remain susceptible to only a few antimicrobial agents, which means that infections caused by these strains are very difficult to treat.


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