Pertussis in infancy and the association with respiratory and cognitive disorders at toddler ageArchived
The authors acknowledge several methodological limitations in this study, and the data refer to a small sample of children.
de Greeff SC, van Buul LW, Westerhof A, Wijga AH, van de Kassteele J, Oostvogels B, van der Maas NA, Mooi FR, de Melker HE. Vaccine. 2011 Oct 26;29(46):8275-8.
The authors acknowledge several methodological limitations in this study, and the data refer to a small sample of children. Furthermore, we can only speculate on biological reasons underlying the association between severe pertussis in early life and respiratory morbidity on toddler age. More research is required to support the results found in this pilot study. However, given the increase in pertussis infections observed in the past decade, these results emphasise the need to prevent pertussis in infants and, if confirmed, they could favourably impact on (cost-) effectiveness ratios of pertussis vaccination strategies.
Pertactin-Negative Variants of Bordetella pertussis in the United States
11 Feb 2013 - This letter to the editor raises the issue of the adaptation of B. pertussis to vaccine selection pressure as one of the reasons for the increase number of cases of whooping cough reported in several countries.
Waning Protection after Fifth Dose of Acellular Pertussis Vaccine in ChildrenArchived
24 Sep 2012 - The authors assess the risk of pertussis in children in California relative to the time since the fifth dose of DTaP from 2006 to 2011 (this period included a large outbreak in 2010).
Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type BArchived
28 Mar 2012 - This study, strong of an almost complete follow-up of all children born in Denmark from 2003 to 2008, provides evidence that the DTaP-IPV-HiB vaccine is not associated to an overall increased risk of febrile seizures and epilepsy.