Pneumococcal meningitis in French children before and after the introduction of pneumococcal conjugate vaccineArchived

ECDC comment

In the context of an active nationwide surveillance network, this study describes pneumoccocal meningitis in children aged from 1 day to 15 years during a 8 year study period (2001-2008) in France. 951 pneumoccocal meningitis cases were reported among 3312 children with bacterial meningitis. T

Corinne Levy, Emmanuelle Varon, Edouard Bingen, Aurelie Lecuyer, Michel Boucherat, Robert Cohen and The Bacterial Meningitis Study Group. Pediatr Infect Dis J. 2011;30 (2):168–170.

The number of cases did not decline from the prevaccine period (2001-2002) to the postvaccine period (2007-2008), accounting for 30% of all bacterial meningitis in both periods. However, the mean age of onset between both periods increased significantly: 2.3 vs 3.8 years (median 0.8 vs 1.5y). In the overall population, cases caused by vaccine serotypes fell from 65.7% in the prevaccine period to 17.5% in the post vaccine period, mainly involving serotype 19A in children<2y and 7F in older children. Before PCV7 implementation, the potential coverage of PCV7, PCV10, and PCV13 were 65.7%, 69.7%, and 86.7%, respectively, compared with 17.7%, 34.3%, and 60.6% after PCV7 implementation.The proportion of penicillin-resistant strains decreased between prevaccine period and postvaccine period (8.6% and 3.6% respectively).