Systematic review of the effectiveness of infection control measures to prevent the transmission of extended-spectrum beta-lactamase-producing Enterobacteriaceae through cross-border transfer of patients
Extended-spectrum β-lactamases (ESBL-E) are associated with an increase of morbidity, mortality, and healthcare costs. Identifying effective infection control measures is an important step in order to prevent patients from becoming colonised or infected with these multidrug-resistant organisms. This systematic review seeks to identify evidence for the effectiveness of targeted infection control measures to control the spread and transmission of ESBL-E when transferring patients between healthcare settings, especially when the transfer is cross-border. Evidence from this review will be used by ECDC to develop guidance on this topic to help curb the transmission of ESBL E into healthcare settings.
Enterobacteriaceae that produce extended-spectrum β-lactamases (ESBL-E) carry plasmid-encoded enzymes that can efficiently hydrolyse and confer resistance to a variety of β-lactam antibiotics, but not to carbapenems or cephamycins. These enzymes are predominantly found in Escherichia coli ( E. coli ) and Klebsiella pneumoniae ( K. pneumoniae ), although present also in other members of the Enterobacteriaceae.
The emergence and spread of ESBL-E is a public health threat, especially because infections caused by ESBL-E are associated with an increase of morbidity, mortality, and healthcare costs. Curbing the spread of ESBL-E in healthcare facilities after their importation is important – as is controlling transmission in areas where they have become endemic – because they are associated with poor patient outcomes. Identifying the infection control measures that are effective is an important step in order to prevent patients from becoming colonised or infected with these multidrug-resistant organisms (MDROs). Although some European countries have addressed the spread of ESBL-E by creating new or modified guidelines/strategies for other MDROs, or national/local task forces, few official guidelines or guidance documents relating to infection control measures for ESBL-E have been published.
Surveillance of COVID-19 in long-term care facilities in the EU/EEA
29 Nov 2021 - ECDC has worked with EU/EEA countries to develop a methodology for regular national reporting of existing national surveillance data on COVID-19 in LTCFs, aiming for maximum feasibility. This is to enable ECDC to communicate timely information on epidemiological trends of COVID-19 in LTCFs, in support of national and EU/EEA-level preparedness and response activities.
Assessment of electronic health records for infectious disease surveillance
19 Nov 2021 - This is the final report for the mapping study ‘Assessment of electronic health records (EHRs) for infectious disease surveillance, prevention and control’. The study was commissioned by ECDC and was delivered by RAND Europe. The objective of the project is to investigate the current status of EHR systems in the European Union and European Economic Area (EU/EEA) and the potential capacity for the use of these data for surveillance of infectious diseases within ECDC’s remit.
Digital technologies for the surveillance, prevention and control of infectious diseases - A scoping review of the research literature
16 Nov 2021 - The objective of this scoping review is to obtain an estimate of the size and nature of the scientific literature available on digital technologies with the potential to benefit or disrupt key public health functions, focusing on infectious disease surveillance, prevention and control.