Rapid risk assessment: Risk related to the use of ‘do-it-yourself' CRISPR-associated gene engineering kit contaminated with pathogenic bacteria
On 24 March 2017, the German authorities reported the contamination of a ‘do-it-yourself’ bacterial gene engineering CRISPR kit produced in the US. The kit was contaminated with pathogenic bacteria (risk group 2), including some bacteria that are multidrug-resistant and ESBL-producing. The risk of infection by the contaminating strains in the kit is low for the users of the kit, assuming that they are healthy people. The contribution of the kit to the burden of antimicrobial resistance in the EU/EEA population and environment is marginal, and the risk associated with the kits is considered very low.
Rapid risk assessment: Outbreak of carbapenemase-producing Enterobacterales in Lithuania, 2019
18 Dec 2019 - Between 1st February and 26th November 2019, 199 cases of Klebsiella pneumoniae carbapenemase (KPC)-producing carbapenem-resistant Enterobacterales (KPC-CRE) have been detected in Lithuania.
Outbreak of carbapenemase-producing (NDM-1 and OXA-48) and colistin-resistant Klebsiella pneumoniae ST307, north-east Germany, 2019
28 Oct 2019 - Germany has reported an outbreak of carbapenemase-producing (NDM-1 and OXA-48) and colistin-resistant Klebsiella pneumoniae sequence type (ST) 307. As of 21 October 2019, 17 patients in three hospitals and one rehabilitation clinic in Mecklenburg-West Pomerania in north-east Germany have been affected. Six of the 17 cases presented with clinical symptoms of infection, while 11 were identified as be carriers.
Rapid risk assessment: Regional outbreak of New Delhi metallo-betalactamase-producing carbapenem-resistant Enterobacteriaceae, Italy, 2018–2019
4 Jun 2019 - A large outbreak of New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Enterobacteriaceae (CRE) has been reported from the Tuscany region in Italy. Between November 2018 and May 2019, seven Tuscan hospitals notified a total of 350 cases.