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Scientific and technical publications

Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to SARS-CoV-2 in individuals aged 20 years and older – fourth update

Guidance - 16 Mar 2023

This update reports on one of the ECDC multi-country studies that is centred around the hospital setting and severe disease, with the aim of assessing vaccine effectiveness against severe acuterespiratory infection (SARI) due to laboratory-confirmed SARS-CoV-2 within the ECDC VaccineEffectiveness, Burden and Impact Studies infrastructure (VEBIS) [1,2].

Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 20 years and older, ECDC multi-country study – fourth update - EN - [PDF-923.36 KB]
  • Coronavirus
  • COVID-19
  • Immunisation
  • Public health threat
  • Respiratory diseases
  • SARS-CoV-2 variants
  • Vaccine effectiveness

Scientific and technical publications

Overview of the implementation of COVID-19 vaccination strategies and deployment plans in the EU/EEA

Monitoring - 3 Mar 2023

This report provides an updated overview on the progress of national COVID-19 vaccination strategies and deployment in European Union/European Economic Area (EU/EEA) countries, including updates on overall vaccine uptake and uptake by target group and vaccination strategies and policies.

Overview of the implementation of COVID-19 vaccination strategies and deployment plans in the EU/EEA, 3 March 2023 - EN - [PDF-1.35 MB]
  • Coronavirus
  • COVID-19
  • EU/EEA
  • Immunisation
  • Public health threat
  • Scientific advice

Scientific and technical publications

Protocol for a COVID-19 vaccine effectiveness study using health data registries

Guidance - 30 Jan 2023

This protocol presents a common methodology to estimate vaccine effectiveness (VE) for COVID-19, using established health data registries in participating EU/EEA Member States.

Protocol for a COVID-19 vaccine effectiveness study using health data registries - EN - [PDF-668.71 KB]
  • Coronavirus
  • COVID-19
  • Immunisation
  • Vaccine effectiveness

Scientific and technical publications

Core protocol for ECDC studies of COVID-19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratory-confirmed with SARS-CoV-2 or with seasonal influenza - Version 2.0

Guidance - 30 Jan 2023

This core protocol for ECDC studies of vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection laboratory-confirmed with SARS-CoV-2 or with influenza, version 2.0, represents an update to the main elements for a multi-country hospital-based study of COVID-19 vaccine effectiveness in patients hospitalised with Severe Acute Respiratory Infection (SARI), already published as version 1.0.

Core protocol for ECDC VEBIS studies of vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratory-confirmed with SARS-CoV-2 or with seasonal influenza - Version 2.0 - EN - [PDF-1.62 MB]
  • Coronavirus
  • COVID-19
  • Immunisation
  • Microbiology
  • Vaccine effectiveness

Scientific and technical publications

Interim analysis of COVID-19 vaccine effectiveness in healthcare workers, an ECDC multi-country study, May 2021–July 2022

Monitoring - 21 Nov 2022

This document reports on one of ECDC’s multi-country studies in the hospital setting to measure product-specific COVID-19 VE against any laboratory-confirmed SARS-CoV-2 infection among healthcare workers (HCWs) eligible for vaccination.

Interim analysis of COVID-19 vaccine effectiveness in healthcare workers, an ECDC multi-country study, May 2021–July 2022 - EN - [PDF-989.41 KB]
  • Coronavirus
  • COVID-19
  • Immunisation
  • Vaccine effectiveness

Scientific and technical publications

Generic protocol for ECDC studies of COVID-19 vaccine effectiveness against confirmed SARS-CoV-2 using healthcare worker cohorts, version 2.0

Monitoring - 21 Nov 2022

This generic protocol for ECDC studies describes the design and methods for a prospective multi-country cohort study of hospital-based healthcare workers (HCWs) to evaluate the effectiveness of COVID-19 vaccine in preventing laboratory-confirmed SARS-CoV-2 infection.

Generic protocol for ECDC studies of COVID-19 vaccine effectiveness against confirmed SARS-CoV-2 using healthcare worker cohorts v2 - EN - [PDF-1.09 MB]
  • COVID-19
  • Immunisation
  • Vaccine effectiveness

Scientific and technical publications

Pilot protocol for a COVID-19 vaccine effectiveness study using health data registries

Guidance - 19 Sep 2022

This pilot protocol is primarily intended to guide the implementation of a first pilot ECDC-funded study using routinely collected data, and includes a concise overview of the systems of the countries included in the pilot study.

Pilot protocol for a COVID-19 vaccine effectiveness study using health data registries - EN - [PDF-1.1 MB]
  • COVID-19
  • Immunisation
  • SARS-CoV-2 variants
  • Vaccine effectiveness

Scientific and technical publications

Long-term qualitative scenarios and considerations of their implications for preparedness and response to the COVID-19 pandemic in the EU/EEA

Guidance - 29 Aug 2022

This document sets out a number of scenarios that are intended to be plausible, internally consistent, and coherent descriptions of possible futures.

Long-term qualitative scenarios and considerations of their implications for preparedness and response to the COVID-19 pandemic in the EU/EEA - EN - [PDF-523.1 KB]
  • COVID-19
  • Immunisation
  • Pandemic preparedness
  • Preparedness and prevention

Scientific and technical publications

Generic protocol for COVID-19 vaccine effectiveness studies at long-term care facilities in the EU/EEA

Guidance - 24 Aug 2022

This protocol outlines the methods for a prospective cohort study in long-term care facilities (LTCFs) to evaluate the effectiveness of COVID-19 vaccines in preventing laboratory-confirmed SARS-CoV-2 symptomatic infection in LTCF residents.

Generic protocol for COVID-19 vaccine effectiveness studies at long-term care facilities in the EU/EEA - EN - [PDF-1.01 MB]
  • COVID-19
  • High-risk groups
  • Immunisation
  • Public health threat

Scientific and technical publications

Preliminary public health considerations for COVID-19 vaccination strategies in the second half of 2022

Guidance - 18 Jul 2022

This document offers an overview of the available scientific and epidemiological evidence and provides public health considerations to support decisions on the implementation of additional booster doses of COVID-19 vaccine.

Preliminary public health considerations for COVID-19 vaccination strategies in the second half of 2022 - EN - [PDF-2.31 MB]
  • Coronavirus
  • COVID-19
  • Immunisation
  • Public health threat

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