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This document provides guidance on diagnostic testing, molecular characterisation and metagenomic analysis for suspect cases of severe acute hepatitis of unknown aetiology.

This report of the EFSA and ECDC presents the results of zoonoses monitoring activities carried out in 2020 in 27 EU Member States (MS) and nine non-MS.

An increase in severe acute hepatitis cases of unknown aetiology among previously healthy children was first reported by the United Kingdom (UK) on 5 April 2022.

This document provides the final report of a scoping review undertaken as part of a wider study on the ‘Assessment of point of care testing devices for infectious disease surveillance, prevention and control’ that was commissioned by ECDC and undertaken by RAND Europe between November 2019 and April 2020. 

This reporting protocol is intended for reporting national case-based data for surveillance of hepatitis of unknown origin from all the countries and areas of the WHO European Region, including the 27 countries of the European Union (EU) and the additional three countries of the European Economic Area (EEA), to the European level.

In 2017, 381 confirmed brucellosis cases were reported in the EU/EEA. The notification rate in the EU/EEA was 0.09 cases per 100 000 population. The highest rates were reported in southern EU Member States (Greece, Italy and Portugal). The highest rate was observed in 25–44-year-old males (0.16 per 100 000). The notification rate was stable from 2013–2017 in the EU/EEA.

This report of the EFSA and ECDC presents the results of zoonoses monitoring activities carried out in 2019 in 36 European countries (28 Member States (MS) and eight non-MS).