Public health guidance on use of interferon-gamma release assays in support of TB diagnosis
This report sets out the evidence on IGRAs and their use in the diagnosis of latent and active tuberculosis.After reviewing all available evidence, the expert panel concluded that ‘IGRAs should not replace the standard diagnostic methods for diagnosing active TB.’
Risk assessment: Laboratory-created A(H5N1) viruses transmissible between ferrets
The results of two, as yet unpublished, investigations of laboratory-induced genetic changes in avian influenza A(H5N1) viruses have been reported to have found that a surprisingly few number of changes make the viruses transmissible between ferrets, the most commonly used model for the way influenza behaves in humans. The possibility that this could have resulted in the development in laboratories of A(H5N1) influenza viruses transmissible between humans has caused concern for public safety and generated unusually high levels of debate in the scientific community. This report summarises and explains the complex public health and scientific issues around these developments including the positive and negative aspects of some of the responses that have been proposed internationally.
Rapid risk assessment: Potential contamination of Viaspan® organ perfusion solution
Cluster of monophasic Salmonella Typhimurium with previously unseen MLVA pattern in the EU/EEA
This joint rapid outbreak assessment from ECDC and EFSA assesses a cluster of monophasic Salmonella Typhimurium with an MLVA pattern previously unseen in the EU/EEA.
Systematic review of the effectiveness of infection control measures to prevent the transmission of extended-spectrum beta-lactamase-producing Enterobacteriaceae through cross-border transfer of patients
This systematic review seeks to identify evidence for the effectiveness of targeted infection control measures to control the spread and transmission of ESBL-E when transferring patients between healthcare settings, especially when the transfer is cross-border.
Expert Opinion on the introduction of next-generation typing methods for food- and waterborne diseases in the EU and EEA
This report describes many of the aspects that should be taken into account. It systematically covers the entire process from sample provision and sequencing to data analysis and collaboration with other organisations.
Expert opinion on whole genome sequencing for public health surveillance
This document sets out ECDC's five year vision for using whole genome sequencing (WGS) technology within the context of its agreed strategy and roadmap for integrating typing data into EU level surveillance and cross-border outbreak assessment.
Re-emerging multi-country WGS-defined outbreak of Salmonella Enteritidis, MLVA type 2-12-7-3-2 and 2-14-7-3-2, 6 February 2017
This rapid risk assessment assesses the recurrent multi-country outbreak of Salmonella Enteritidis due to a persistent source of infection, with current or recent exposure in at least four EU/EEA Member States.
Rapid risk assessment: multidrug-resistant tuberculosis in migrants, multi-country cluster - 2nd update, 27 March 2017
This second update provides information regarding the risk of EU transmission of an MDR TB clone initially detected in seven asylum seekers from the Horn of Africa who currently reside in Switzerland.