In September 2010, two cases of autochthonous dengue fever were diagnosed in metropolitan France for the first time. The cases occurred in Nice, southeast France, where the vector Aedes albopictus is established.

As of 3 February 2013, the Portuguese Ministry of Health has reported 2 164 cases of dengue infection from the Autonomous Region of Madeira since 3 October 2012. No deaths or cases of severe dengue have been reported. All reported cases refer to the resident population of the island.

On 3 August 2012, a probable case of dengue infection was reported in a resident in west Greece (Agrinio). The 84 year old patient, who had severe underlying conditions and septicaemia, died on 30 August 2012.

The dengue case reported in the epidemiological update of 7 September has now been discarded based on additional laboratory results.

On 3 October, the Public Health Authority of Portugal (Direção-Geral da Saúde) reported two cases of dengue infection in patients residing in the Autonomous Region of Madeira, Portugal.

The reported number is now 37 confirmed and 262 probable cases. Thirty people needed hospitalisation and six are still in hospital.

On 24 October 2012 the Portuguese Ministry of Public Health (Direcção-Geral da Saúde) confirmed 52 cases of dengue fever and 404 probable cases, compared to 37 confirmed and 262 probable cases in their last update of 17 October.

As of 4 November 1 148 cases of dengue infection have been reported, of which 517 were laboratory confirmed. The case definition has been revised and an automated surveillance system has been set up with the support from ECDC. The changes that were put in place meant that additional cases were identified retrospectively.

As of 9 December 2012, the Portuguese Ministry of Health has reported 2 050 cases of dengue infection from the Autonomous Region of Madeira. During the outbreak, 121 people have been hospitalised and no deaths or cases of severe dengue have been reported. Two patients remained in hospital as of 9 December 2012.

Since the beginning of 2018 and as of 14 May, 2 980 autochthonous cases of dengue have been reported in Réunion. The main areas affected are in the western part of the island. The most prevalent serotype among dengue cases is DENV-2 and the main vector implicated in the outbreak is Aedes albopictus.