This website is part of the ECDC (European Centre for Disease Prevention and Control) network

EU case definition

West Nile fever in humans is a notifiable disease at the European Union (EU) level according to Commission Decision 2009/312/EC.

 

The case definition for reporting human cases of West Nile fever at EU level is outlined in Commission Decision of 28/IV/2008.

It includes the following criteria and case classification:

Clinical criteria

Any person with fever OR at least one of the following two:
- Encephalitis
- Meningitis

 

Laboratory criteria

1. Laboratory test for case confirmation
At least one of the following four:
- Isolation of WNV from blood or CSF
- Detection of WNV nucleic acid in blood or CSF
- WNV specific antibody response (IgM) in CSF
- WNV IgM high titre AND detection of WNV IgG, AND confirmation by neutralisation

 

2.  Laboratory test for a probable case
WNV specific antibody response in serum. Laboratory results need to be interpreted according to flavivirus vaccination status.

Epidemiological criteria

At least one of the following two epidemiological links:
- Animal to human transmission (residing, having visited or having been exposed to mosquito bites in an area where WNV is endemic in horses or birds)
- Human to human transmission (vertical transmission, blood transfusion, transplants)

 

Case classification

Probable case
Any person meeting the clnical criteria AND with at least one of the following two:
- an epidemiological link
- a laboratory test for a probable case

Confirmed case
Any person meeting laboratory criteria for case confirmation.

 

 HEALTH TOPICS A-Z

 
Click a letter to find the health topic
© European Centre for Disease Prevention and Control (ECDC) 2005 - 2014