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TBE situation in individual European countries 

Austria
Previously a high incidence country, increasing immunisation coverage has been associated with a steady decline in TBE incidence in Austria. The number of cases are today about 10% of what they were in the pre-vaccine era. In the five-year period from 2004 to 2009, an average of 54 (272/5, range 33 to 65) TBE cases were reported per year. There were 8 deaths from TBE in the same period.

Czech Republic
The TBE virus was first isolated in 1948 in the Czech Republic. TBE is present in all parts of the country with the highest incidence in the South Bohemia region and the Czech-Moravia highlands. There was a marked increase in the annual incidence starting from 1993. During the period from 1965 to 1992, the mean annual incidence was 310 cases per year (8690 cases over 28 years) compared to 627 cases per year in the 1993 to 2009 period (10 667 cases over 17 years). Sixty-four cases of alimentary transmission via unpasteurized milk and milk products from sheep and goats were recorded from 1997 to 2008.  Climatic changes are believed to play a role in the increased number of TBE infections in the Czech Republic. A collaboration between the National Institute of Public Health and the Czech Hydrometeorological Institute has resulted in the development of a software application, TICKPRO, that produces 4-day forecasts on tick host-seeking activity. The forecasts are communicated to the public together with advice on how best to avoid tick bites. The National Institute of Public Health provides information to the public on TBE. TICKPRO. NIPH also publishes statistics and reports on TBE and other infectious diseases in the monthly epidemiological bulletin “Zpravy Epidemiologie a Mikrobiologie” 

Estonia
TBE has been a notifiable disease in Estonia since 1949, where it is the leading cause of viral encephalitis. There has been an upward trend in the number of new cases since the 1970s. The peak season is from May to September. In the areas with the highest transmission more than five percent of ticks carry the virus. From 2003 to 2007, an average of 179 cases were reported annually in a population of 1.34 million], and Estonia is among the countries with the highest incidence rates in Europe. The highest TBE risk exists in western Estonia (Pärnumaa, Läänemaa), eastern Estonia (Ida-Virumaa), on Saaremaa (an island in the west), and in south-eastern Estonia (Polvamaa, Tartumaa). In 2005, a cluster of 27 TBE cases were linked to the consumption of unpasteurised goat milk served in a supermarket promotion illustrating that the virus is present in the milk from infected dairy live stock, particularly goats, and can infect humans when ingested.

Finland
The most northern endemic TBE areas in Europe are found in Finland, where between 1995 and 2009 an average of 20 cases were reported annually, with a record number of 41 cases in 2000. The most important endemic areas are the archipelagos of Åland and Turku, and the Kokkola and Lappeenranta regions. The highest risk is in the Åland archipelago where the number of new TBE cases ranged from 3 to 26 per year during the last ten years (2000–2009), which translates to a mean annual incidence of about 49 per 100 000 population. Free TBE immunisation from the age of seven was introduced in Åland in 2007. The National Institute for Health and Welfare provides information and advice for the public on tick-borne diseases in Finnish, Swedish and English.

Germany
On average 318 (2863/9, range 237–546) TBE cases per year were reported in Germany from 2001 to 2009. The two southern states of Baden-Wϋrttemberg and Bayern have the highest incidence rate and the majority of cases (86%) occur here. Germany has an elaborate system of TBE risk assessment with annually updated epidemiological maps at the level of counties (Kreis). The risk is assessed based on the mean incidence measured over sliding five-year intervals for each of the 429 counties and cities in the country. A Kreis is classified as a TBE risk area if the incidence is significantly higher than 1 case per 100000 population per five-year interval. In 2010, 136 out of 429 counties were classified as TBE risk areas (Baden-Wϋrttemberg 42, Bayern 78, Hessen 8, Thϋringen 7, Rheinland-Pfalz 1).
Based on the assessment, the epidemiological map of TBE risk by county is updated and published annually in the Epidemiological Bulletin (Epidemiologisches Bulletin RKI) and communicated to health professionals. The 2010 TBE risk map can be reviewed in the 17/2010 issue of the bulletin. The Robert Koch Institute (RKI) provides information and advice on TBE vaccination for health professionals and the public.

Hungary
TBE surveillance in Hungary is part of the mandatory syndromic reporting of ‘infectious encephalitis’. Blood samples from all reported cases are tested at the National Reference Laboratory. A total of 5031 TBE cases were diagnosed in the 1982–2007 period with a mean of 191 cases (range 54–422) per year and a case fatality ratio of 0.5% (24/5031). There was a significant downward trend in the number of reported TBE cases in the period: the national incidence declined from about 3 per 100 000 population at the start of the period to 0.6 per 100000 population at the end. In 1.6% of the cases the transmission was thought to be via infected milk. The highest risk of TBE infection is in the Transdanubia region in the western part of the country where the mean annual incidence by county was 7–14 per 100000 population. The National Institute of Pharmacy provides information to the public and incidence data is available from the National Centre for Epidemiology.

Lithuania
TBE is present in all districts of Lithuania, and TBE cases have been registered in Lithuania since the 1960s. The annual number of cases increased in the 1990s, with the highest recorded TBE incidences in 1997 (645 cases, 17.4/100000), 2003 (763 cases, 21.95/100000) and 2009 (605 cases, 17.8/100000). On average, 422 cases of TBE were reported per year in the seven-year period from 2003 to 2009 (range 220–763). An analysis of blood samples from 1488 healthy individuals across Lithuania in 2000 found 2.96% of the individuals to be positive for TBE, indicating a previous infection. A positive TBE test was found to be associated with owning a summer cottage, drinking unpasteurised goat milk and having suffered an undiagnosed episode of encephalitis in the past (people with confirmed TBE in the past were excluded from the study).
The main transmission route is directly from ticks to humans but every year a few people become infected from raw milk. In 2003, four clusters with a total of 22 cases of TBE were linked to the consumption of unpasteurised milk and four cases of alimentary transmission were registered in 2009.

Norway
Reporting of TBE has been mandatory in Norway since 1975. The first ever documented locally acquired infection was reported in 1997. On average, ten endemic cases were reported per year in the 2006 to 2009 period, with most infections acquired in the south-eastern part of the country (Vest-Agder and Aust-Agder). Folkehelseinstituttet, Norway’s public health institute, provides information and advice on tick-borne diseases.

Slovenia
Endemic foci of TBE are spread mostly in northern and central parts of the country.
Between 1999 and 2008, on average 247 cases were reported annually to the National Institute of Public Health, ranging from the lowest 151 in 1999 to the highest 373 in 2006.
The highest number of TBE cases ever reported was in 1994, with a total of 531 episodes of disease. The National Institute of Public Health provides information on TBE for the public.

Sweden
TBE is a notifiable disease in Sweden and represents a substantial part of the viral encephalitis disease burden in the country. In the four-year period leading up to 2009, an average of 177 TBE cases were reported annually, and the number of TBE cases increased by 71% from 131 cases in 2005 to 224 cases in 2008. Most of the infections were acquired in the counties of Stockholm, Södermanland and Uppsala, and along the southern part of Lake Vänern in the county of Västra Götaland. Every year sporadic cases occur across southern Sweden. In 2008, a locally acquired infection was reported from the county of Västerbotten, which is the highest latitude for endemic TBE infection documented in Sweden. TBE occurs from April to December in Sweden, with the peak incidence between May and July.
Information to the public on tick-borne diseases in Sweden is available from the website of the Swedish Institute for Infectious Disease Control.


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