Between 1 January and 4 August 2006, a total of 242 laboratory confirmed cases and 20 deaths of Congo-Crimean hemorrhagic fever (CCHF) were reported in Turkey. Six provinces in the Black Sea and Central Anatolia region are the most affected (Tokat, Gümüshane, Amasya, Çorum, Yozgat and Sivas provinces). No cases have been reported from popular tourist resorts at the Mediterranean coast. Compared with previous years, this number may suggest increased activity of the virus in the area, although detection, diagnosis and notification have improved. In Turkey, CCHF in humans was first documented in 2002.